作者
Sarah J Marzi, Karen Sugden, Louise Arseneault, Daniel W Belsky, Joe Burrage, David L Corcoran, Andrea Danese, Helen L Fisher, Eilis Hannon, Terrie E Moffitt, Candice L Odgers, Carmine Pariante, Richie Poulton, Benjamin S Williams, Chloe CY Wong, Jonathan Mill, Avshalom Caspi
发表日期
2018/6/1
期刊
American Journal of Psychiatry
卷号
175
期号
6
页码范围
517-529
出版商
American Psychiatric Association
简介
Objective
DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become “embedded” in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether early-life victimization stress is associated with genome-wide DNA methylation.
Method
The authors tested the hypothesis that victimization is associated with DNA methylation in the Environmental Risk (E-Risk) Longitudinal Study, a nationally representative 1994–1995 birth cohort of 2,232 twins born in England and Wales and assessed at ages 5, 7, 10, 12, and 18 years. Multiple forms of victimization were ascertained in childhood and adolescence (including physical, sexual, and emotional abuse; neglect; exposure to intimate-partner violence; bullying; cyber-victimization; and crime).
Results
Epigenome-wide analyses of polyvictimization across childhood and …
学术搜索中的文章
SJ Marzi, K Sugden, L Arseneault, DW Belsky… - American Journal of Psychiatry, 2018