作者
Line Jee Hartmann Rasmussen, Terrie E Moffitt, Louise Arseneault, Andrea Danese, Jesper Eugen-Olsen, Helen L Fisher, HonaLee Harrington, Renate Houts, Timothy Matthews, Karen Sugden, Benjamin Williams, Avshalom Caspi
发表日期
2020/1/1
期刊
JAMA pediatrics
卷号
174
期号
1
页码范围
38-47
出版商
American Medical Association
简介
Importance
Childhood stress exposure is associated with inflammation as measured by C-reactive protein (CRP) and interleukin 6 (IL-6). However, findings are inconsistent and effect sizes are small. The addition of soluble urokinase plasminogen activator receptor (suPAR), a new biomarker of chronic inflammation, may improve measurement of stress-related inflammatory burden.
Objectives
To assess whether exposure to adverse experiences, stress, and violence is associated with an increase in suPAR levels in young people and to test the hypothesis that measuring suPAR in addition to CRP or IL-6 levels improves the assessment of the inflammatory burden associated with early-life stress.
Design, Setting, and Participants
This cohort study included 1391 participants from a 1994 to 1995 birth cohort of twins from the nationally representative Environmental Risk Longitudinal Twin Study in the United Kingdom …
学术搜索中的文章
LJH Rasmussen, TE Moffitt, L Arseneault, A Danese… - JAMA pediatrics, 2020