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In the contemporary era, the increasing complexities in national security necessitate the continuous evolution within the sphere of chemical, biological, radiological, and nuclear (CBRN) threat detection. This study presents a detailed analysis of the interdisciplinary technologies pivotal to chemical hazard detection systems, thereby offering an analytical framework to enhance national security strategies. The authors examine the fundamental principles of standoff and point detectors, focusing on their role in safeguarding first responders in civilian contexts. Furthermore, the intricacies of current technologies were explored, highlighting their functionalities and inherent limitations. This research aims to pinpoint optimal technologies that meet the stringent demands of national security, facilitating a resilient response mechanism to chemical threats. By fostering interdisciplinary collaboration, this study contributes significantly towards building a fortified national security framework, adept at navigating the complex and evolving threat dynamics.