查看文章

Autosomal recessive dedicator of cytokinesis 8 (DOCK8^−/−) and autosomal dominant signal transducer and activator of transcription 3 (STAT3^−/+) deficiencies are inborn errors of immunity (IEI) disorders present with the classic features of eczema and create a dilemma during differentiation from atopic dermatitis (AD). Therefore, an appropriate approach is required for eczema to diagnose DOCK8^−/− and STAT3^−/+ early. Here, we described a set of clinical and immunological variables, including atypical AD localizations and lymphocyte subsets, to differentiate DOCK8^−/− or STAT3^−/+ from AD.

This multicenter study involved 100 patients with DOCK8^−/− and STAT3^−/+ and moderate/severe AD. We recruited disease manifestations, including detailed localizations of eczema, infections, and allergy. Principle component analysis (PCA) was used to discriminate DOCK8^−/− or STAT3^−/+ from AD.