作者
Philipp Karschnia, Frank J Barbiero, Michaela H Schwaiblmair, Leon D Kaulen, Joseph M Piepmeier, Anita J Huttner, Kevin P Becker, Robert K Fulbright, Joachim M Baehring
发表日期
2020/1/31
来源
Neuro-Oncology Practice
卷号
7
期号
1
页码范围
118-126
出版商
Oxford University Press
简介
Background
Leptomeningeal dissemination (LD) in adults is an exceedingly rare complication of low-grade neuroepithelial CNS tumors (LGNs). We aimed to determine relative incidence, clinical presentation, and predictors of outcome.
Methods
We searched the quality control database of the Section of Neuro-Oncology, Yale Cancer Center, for patients with LGN (WHO grade I/II) seen between 2002 and 2017. For cases complicated by LD, we recorded demographics, clinical signs, histopathological diagnosis, and imaging findings. A comprehensive literature review was performed.
Results
Eleven consecutive patients with LD were identified, representing 2.3% of individuals with LGN seen at our institution between 2002 and 2017 (n = 475). Ependymoma was the predominant histological entity. Mean time interval from diagnosis of LGN to LD was 38.6 ± …
学术搜索中的文章
Leptomeningeal dissemination of low-grade neuroepithelial CNS tumors in adults: a 15-year experience
P Karschnia, FJ Barbiero, MH Schwaiblmair… - Neuro-Oncology Practice, 2020