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Logistics problems play a significant role in an emergency situation. During and after a critical circumstance (like pandemic COVID-19), it is an important task to active the opened- and closed-loop system through an efficient and resilient supply chain network. This paper considers a multi-objective multi-product multi-period two-stage sustainable opened- and closed-loop supply chain planning to maintain supply among production centers and various hospitals during COVID-19 pandemic situation. To build a less contagious network, transportation problem and pick-up-delivery vehicle routing problem are designed as two stages, respectively to carry out distribution. We allow a mixed uncertain environment by considering uncertain-random parameters in the proposed model to express ambiguity in real-life data. A multi-attribute decision making approach is suggested to determine the priorities of affected areas …