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From April to June, 2020, minors presenting with skin manifestations and symptoms of COVID-19 themselves or any of first-degree relatives (ie fever, influenza-like, respiratory, Ear–Nose–Throat and/or digestive symptoms), were enrolled. Epidemiological and clinical information, description of households and biological results including three types of SARS-CoV-2 tests [nasal PCR (systemic symptoms within the past 48 h), serology (IgG, techniques: Abbott ARCHITECT) and interferon-c (IFN-c)-ELISPOT-assay] were collected. IFN-c-ELISPOT-assay, an early (since day 5) qualitative and quantitative analysis, evaluates specific memory T cells by quantifying the IFN-c production after a short-term stimulation with SARS-COV-2 peptide. At least one test among serology and IFN-c-ELISPOT-assay was performed on patients with chilblains. Thirty patients (20 boys, average= 9.5 years) representing 28 households were …