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Recent achievement in self-interference cancellation algorithms enables potential application of full-duplex (FD) in 5G radio access systems. The exponential growth of data traffic in 5G can be supported by having more spectrum and higher spectral efficiency. FD communication promises to double the spectral efficiency by enabling simultaneous uplink and downlink transmissions in the same frequency band. Yet for cellular access network with FD base stations (BS) serving multiple users (UE), additional BS-to-BS and UE-to-UE interferences due to FD operation could diminish the performance gain if not tackled properly. In this article, we address the practical system design aspects to exploit FD gain at network scale. We propose efficient reference signal design, low-overhead channel state information feedback and signalling mechanisms to enable FD operation, and develop low-complexity power control and scheduling algorithms to effectively mitigate new interference introduced by FD operation. We extensively evaluate FD network-wide performance in various deployment scenarios and traffic environment with detailed LTE PHY/MAC modelling. We demonstrate that FD can achieve not only appreciable throughput gains (1.9x), but also significant transmission latency reduction~(5-8x) compared with the half-duplex system.