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CCross-layer scheduling and coding for the coexistence between two wireless networks, a primary network and a secondary network, are considered for the case of two users. Both networks want to transmit to the users, which, however, cannot receive simultaneously on the two radios. Subject to fading and random interruption from the primary network modeled as continuous Markov chain, the secondary network optimizes its scheduling (probing/transmission time/ACK) and coding to maximize its throughput. Performances of several algorithms are considered, which characterize the relationship among important system parameters and shed light on system design.