作者
Ryan Ungaro, Charles N Bernstein, Richard Gearry, Anders Hviid, Kaija-Leena Kolho, Matthew P Kronman, Souradet Shaw, Herbert Van Kruiningen, Jean-Frederic Colombel, Ashish Atreja
发表日期
2014/11/1
来源
Official journal of the American College of Gastroenterology| ACG
卷号
109
期号
11
页码范围
1728-1738
出版商
LWW
简介
OBJECTIVES:
The objective of this study was to perform a meta-analysis investigating antibiotic exposure as a risk factor for developing inflammatory bowel disease (IBD).
METHODS:
A literature search using Medline, Embase, and Cochrane databases was performed to identify studies providing data on the association between antibiotic use and newly diagnosed IBD. Included studies reported Crohn’s disease (CD), ulcerative colitis (UC), or a composite of both (IBD) as the primary outcome and evaluated antibiotic exposure before being diagnosed with IBD. A random-effects meta-analysis was conducted to determine overall pooled estimates and 95% confidence intervals (CIs).
RESULTS:
A total of 11 observational studies (8 case–control and 3 cohort) including 7,208 patients diagnosed with IBD were analyzed. The pooled odds ratio (OR) for IBD among patients exposed to any antibiotic was 1.57 (95% CI 1.27–1 …
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R Ungaro, CN Bernstein, R Gearry, A Hviid, KL Kolho… - Official journal of the American College of …, 2014