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Currently, with rapid expanding of urban area, the rate of conversion of agricultural land to nonagricultural uses in China is increasing. Zoning farmland protection is an important measure to protect limited land resource. This article presented an innovative approach based on the integrated use of remote sensing, GIS, and artificial immune systems (AIS) for generating farmland protection areas. Some modifications have been made for conventional AIS so that it can be further extended to the solution of zoning problems. The optimal objective is to generate farmland protection areas that minimize development potential and maximize agricultural suitability and spatial compactness. First, utility function by addressing the criteria of farmland protection is incorporated into AIS algorithm. Second, encoding and mutation of antibodies is modified so that it can be suited to the solution of spatial optimization problems. The AIS …