作者
Katerina D Argyri, Dimitra D Dionysiou, Fay D Misichroni, Georgios S Stamatakos
发表日期
2016/12
期刊
Biology direct
卷号
11
期号
1
页码范围
1-31
出版商
BioMed Central
简介
Background
Antiangiogenic agents have been recently added to the oncological armamentarium with bevacizumab probably being the most popular representative in current clinical practice. The elucidation of the mode of action of these agents is a prerequisite for personalized prediction of antiangiogenic treatment response and selection of patients who may benefit from this kind of therapy. To this end, having used as a basis a preexisting continuous vascular tumour growth model which addresses the targeted nature of antiangiogenic treatment, we present a paper characterized by the following three features. First, the integration of a two-compartmental bevacizumab specific pharmacokinetic module into the core of the aforementioned preexisting model. Second, its mathematical modification in order to reproduce the asymptotic behaviour of tumour volume in the theoretical case of a …
引用总数
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