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In this contribution, we propose a robust highly selective channel estimator for downlink Long Term Evolution (LTE) multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) system using neural network. The new method uses the information provided by the reference signals to estimate the total frequency response of the channel in two phases. In the first phase, the proposed method learns to adapt to the channel variations, and in the second phase it predicts the channel parameters. The performance of the estimation method in terms of complexity and quality is confirmed by theoretical analysis and simulations in an LTE/OFDMA transmission system. The performances of the proposed channel estimator are compared with those of least square (LS), decision feedback and modified Wiener methods. The simulation results show that the proposed estimator performs better than the above estimators and it is more robust at high speed mobility.