作者
Sara Alosaimy, Abdalhamid M Lagnf, Athena LV Hobbs, Musa Mubarez, Wesley D Kufel, Taylor Morrisette, Radhika S Polisetty, David Li, Michael P Veve, Sam P Simon, James Truong, Natalie Finch, Veena Venugopalan, Matthew Rico, Lee Amaya, Christine Yost, Ashley Cubillos, Elisabeth Chandler, Megan Patch, Ian Murphy Kelsey Smith, Mark Biagi, Justin Wrin, W Justin Moore, Kyle C Molina, Nicholas Rebold, Dana Holger, Ashlan J Kunz Coyne, Sarah CJ Jorgensen, Paige Witucki, Nikki N Tran, Susan L Davis, George Sakoulas, Michael J Rybak
发表日期
2023/2/1
期刊
Clinical Infectious Diseases
卷号
76
期号
3
页码范围
e1444-e1455
出版商
Oxford University Press
简介
Background
Vancomycin (VAN)-associated acute kidney injury (AKI) is increased when VAN is combined with certain beta-lactams (BLs) such as piperacillin-tazobactam (TZP) but has not been evaluated with ceftolozane-tazobactam (C/T). Our aim was to investigate the AKI incidence of VAN in combination with C/T (VAN/C/T) compared with VAN in combination to TZP (VAN-TZP).
Methods
We conducted a multicenter, observational, comparative study across the United States. The primary analysis was a composite outcome of AKI and risk, injury, failure, loss, end stage renal disease; Acute Kidney Injury Network; or VAN-induced nephrotoxicity according to the consensus guidelines. Multivariable logistic regression analysis was conducted to adjust for confounding variables and stratified Kaplan–Meir analysis to assess the time to nephrotoxicity between the 2 groups …
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S Alosaimy, AM Lagnf, ALV Hobbs, M Mubarez… - Clinical Infectious Diseases, 2023