作者
Nicholas Rebold, Sara Alosaimy, Taylor Morrisette, Dana Holger, Abdalhamid M Lagnf, Iman Ansari, Ana C Belza, Laura Cheaney, Huzaifa Hussain, Shelbye R Herbin, Jacinda Abdul-Mutakabbir, Caitlin Carron, Avnish Sandhu, Teena Chopra, Michael J Rybak
发表日期
2022/6
期刊
Infectious Diseases and Therapy
卷号
11
期号
3
页码范围
1281-1296
出版商
Springer Healthcare
简介
Introduction
Inappropriate antibiotic use in COVID-19 is often due to treatment of presumed bacterial coinfection. Predictive factors to distinguish COVID-19 from COVID-19 with bacterial coinfection or bloodstream infection are limited.
Methods
We conducted a retrospective cohort study of 595 COVID-19 patients admitted between March 8, 2020, and April 4, 2020, to describe factors associated with a bacterial bloodstream coinfection (BSI). The primary outcome was any characteristic associated with BSI in COVID-19, with secondary outcomes including 30-day mortality and days of antibiotic therapy (DOT) by antibiotic consumption (DOT/1000 patient-days). Variables of interest were compared between true BSI (n = 25) and all other COVID-19 cases (n = 570). A secondary comparison was performed between positive blood cultures with true BSI (n = 25) and contaminants (n = 33) on antibiotic use.
Results …
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N Rebold, S Alosaimy, T Morrisette, D Holger… - Infectious Diseases and Therapy, 2022