作者
Fabiola Olivieri, Roberto Antonicelli, Maria Lorenzi, Yuri D'Alessandra, Raffaella Lazzarini, Gabriele Santini, Liana Spazzafumo, Rosamaria Lisa, Lucia La Sala, Roberta Galeazzi, Rina Recchioni, Roberto Testa, Giulio Pompilio, Maurizio C Capogrossi, Antonio Domenico Procopio
发表日期
2013/7/31
期刊
International journal of cardiology
卷号
167
期号
2
页码范围
531-536
出版商
Elsevier
简介
BACKGROUND
Geriatric patients with acute non-ST elevation myocardial infarction (NSTEMI) can frequently present atypical symptoms and non-diagnostic electrocardiogram. The detection of modest cardiac troponin T (cTnT) elevation is challenging for physicians needing to routinely triage these patients. Unfortunately, non-coronary diseases, such as acute heart failure (CHF), may cause cTnT elevation. Circulating microRNAs (miRs) have emerged as biomarkers of MI. However, their diagnostic potential needs to be determined in elderly NSTEMI patients.
METHODS
92 NSTEMI patients (82.6±6.9years old; complicated by CHF in 74% of cases) and 81 patients with acute CHF without AMI (81.3±6.8years old) were enrolled at presentation. A third group comprised 99 age-matched healthy control subjects (CTR). Plasma levels of miR-1, -21, -133a, -208a, -423-5p and -499-5p were analyzed.
RESULTS
MiR-1, -21 …
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F Olivieri, R Antonicelli, M Lorenzi, Y D'Alessandra… - International journal of cardiology, 2013