作者
Michael R Irwin, Steven W Cole
发表日期
2011/9
来源
Nature Reviews Immunology
卷号
11
期号
9
页码范围
625-632
出版商
Nature Publishing Group UK
简介
Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back, through the production of cytokines, to regulate the function of the central nervous system (CNS), and this has effects on behaviour. These signals provide an extrinsic regulatory circuit that links physiological, social and environmental conditions, as perceived by the CNS, with transcriptional 'decision-making' in leukocytes. CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases.
学术搜索中的文章
MR Irwin, SW Cole - Nature Reviews Immunology, 2011