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The 3-D flow of Casson nanofluid over a stretched sheet with chemical reactions, velocity slip, thermal radiation, and Brownian motion have been analyzed. By employing the similarity transformation, the ODE are obtained from the fluidic system PDE. The transformed ODE are handled for the numerical solution of the proposed fluidic problem by incorporating shooting technique. To compare the obtained numerical results, Lobatto 111A method has been implemented, with 5-8 decimal places of accuracy. The numerical data for the fluidic parameters of interest are demonstrated in the tabular form, further few proficient parameters effects like magnetic parameter, Lewis number, stretching rate parameter, the thermal radiation parameter and Prandtl number on velocity, temperature and concentration profiles have been exhibited numerically as well as graphically. By enhancing the velocity slip parameter, increment is examined in temperature and concentration profiles while opposite behavior is recorded in the velocity profile. Both the concentration and temperature profiles decline with the increase in the Stretching rate ratio parameter.