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To successfully deploy femtocells underlaying the macrocell as a heterogeneous network, which has been proven to greatly improve indoor coverage and system capacity, the cross-tier interference among the macrocell and femtocells as well as the intratier interference among femtocells must be mitigated. However, some unique features present a challenge in interference mitigation in a two-tier heterogeneous network such as random deployment for femtocells, nonexistence of macro-femto backhaul coordination, and mandates allowing no modifications of existing macrocells. Carefully examining the existing distributed information acquisition mechanisms, cognitive radio is the most promising solution for two-tier heterogeneous networks. We therefore study possible interference mitigation approaches, including orthogonal radio resource assignment in the time-frequency and antenna spatial domains, as well as …