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The rise of the Internet of Medical Things introduces the healthcare ecosystem in a new digital era with multiple benefits, such as remote medical assistance, real-time monitoring, and pervasive control. However, despite the valuable healthcare services, this progression raises significant cybersecurity and privacy concerns. In this article, we focus our attention on the IEC 60 870-5-104 protocol, which is widely adopted in industrial healthcare systems. First, we investigate and assess the severity of the IEC 60 870-5-104 cyberattacks by providing a quantitative threat model, which relies on Attack Defence Trees and Common Vulnerability Scoring System v3.1. Next, we introduce an intrusion detection and prevention system (IDPS), which is capable of discriminating and mitigating automatically the IEC 60 870-5-104 cyberattacks. The proposed IDPS takes full advantage of the machine learning (ML) and software …