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The rapid evolution of the Internet of Medical Things (IoMT) introduces the healthcare ecosystem into a new reality consisting of smart medical devices and applications that provide multiple benefits, such as remote medical assistance, timely administration of medication and real-time monitoring. However, despite the valuable advantages, this new reality increases the cybersecurity and privacy concerns since vulnerable IoMT devices can access and handle autonomously patients’ data. Furthermore, the continuous evolution of cyberattacks, malware and zero-day vulnerabilities require the development of the appropriate countermeasures. In the light of the aforementioned remarks, in this paper, we present an Intrusion Detection and Prevention System (IDPS), which can protect the healthcare communications that rely on the Hypertext Transfer Protocol (HTTP) and the Modbus/Transmission Control Protocol (TCP …