作者
Qingning Wang, Veryan Codd, Zahra Raisi-Estabragh, Crispin Musicha, Vasiliki Bountziouka, Stephen Kaptoge, Elias Allara, Emanuele Di Angelantonio, Adam S Butterworth, Angela M Wood, John R Thompson, Steffen E Petersen, Nicholas C Harvey, John N Danesh, Nilesh J Samani, Christopher P Nelson
发表日期
2021/8/1
期刊
EBioMedicine
卷号
70
出版商
Elsevier
简介
Background Older age is the most powerful risk factor for adverse coronavirus disease-19 (COVID-19) outcomes. It is uncertain whether leucocyte telomere length (LTL), previously proposed as a marker of biological age, is also associated with COVID-19 outcomes.
Methods We associated LTL values obtained from participants recruited into UK Biobank (UKB) during 2006–2010 with adverse COVID-19 outcomes recorded by 30 November 2020, defined as a composite of any of the following: hospital admission, need for critical care, respiratory support, or mortality. Using information on 130 LTL-associated genetic variants, we conducted exploratory Mendelian randomisation (MR) analyses in UKB to evaluate whether observational associations might reflect cause-and-effect relationships.
Findings Of 6775 participants in UKB who tested positive for infection with SARS-CoV-2 in the community, there were 914 (13.5 …
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Q Wang, V Codd, Z Raisi-Estabragh, C Musicha… - EBioMedicine, 2021