作者
Chaoran Liu, Wing‐Hoi Cheung, Jie Li, Simon Kwoon‐Ho Chow, Jun Yu, Sunny Hei Wong, Margaret Ip, Joseph Jao Yiu Sung, Ronald Man Yeung Wong
发表日期
2021/12
来源
Journal of cachexia, sarcopenia and muscle
卷号
12
期号
6
页码范围
1393-1407
简介
Background
Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly. Although the concept of the gut–muscle axis has been raised, the casual relationship is still unclear. This systematic review analyses the current evidence of gut microbiota effects on muscle/sarcopenia.
Methods
A systematic review was performed in PubMed, Embase, Web of Science, and The Cochrane Library databases using the keywords (microbiota* OR microbiome*) AND (sarcopen* OR muscle). Studies reporting the alterations of gut microbiota and muscle/physical performance were analysed.
Results
A total of 26 pre‐clinical and 10 clinical studies were included. For animal studies, three revealed age‐related changes and relationships between gut microbiota and muscle. Three studies focused on muscle characteristics of germ‐free mice. Seventy‐five per cent of eight faecal microbiota transplantation studies showed …
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C Liu, WH Cheung, J Li, SKH Chow, J Yu, SH Wong… - Journal of cachexia, sarcopenia and muscle, 2021