作者
Valur Emilsson, Gudmar Thorleifsson, Bin Zhang, Amy S Leonardson, Florian Zink, Jun Zhu, Sonia Carlson, Agnar Helgason, G Bragi Walters, Steinunn Gunnarsdottir, Magali Mouy, Valgerdur Steinthorsdottir, Gudrun H Eiriksdottir, Gyda Bjornsdottir, Inga Reynisdottir, Daniel Gudbjartsson, Anna Helgadottir, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Unnur Styrkarsdottir, Solveig Gretarsdottir, Kristinn P Magnusson, Hreinn Stefansson, Ragnheidur Fossdal, Kristleifur Kristjansson, Hjortur G Gislason, Tryggvi Stefansson, Bjorn G Leifsson, Unnur Thorsteinsdottir, John R Lamb, Jeffrey R Gulcher, Marc L Reitman, Augustine Kong, Eric E Schadt, Kari Stefansson
发表日期
2008/3/27
期刊
Nature
卷号
452
期号
7186
页码范围
423-428
出版商
Nature Publishing Group UK
简介
Common human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel the complexity and causes of such diseases. To elucidate the complexity of common human diseases such as obesity, we have analysed the expression of 23,720 transcripts in large population-based blood and adipose tissue cohorts comprehensively assessed for various phenotypes, including traits related to clinical obesity. In contrast to the blood expression profiles, we observed a marked correlation between gene expression in adipose tissue and obesity-related traits. Genome-wide linkage and association mapping revealed a highly significant genetic component to gene expression traits, including a strong genetic effect of proximal (cis) signals, with 50% of the cis signals overlapping between the two tissues profiled. Here we demonstrate an …
引用总数
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