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This work proposes an agent-based simulation system to address challenges in resource constrained multi-project scheduling under uncertainty. The system aims at helping users develop robust schedules by taking care of intra- and inter-dependencies between projects, conflicting demands for limited resources, and the potential knock-on effect of unpredictable events. With the interactive graphical user interface embedded in the system, users are enabled to investigate project process, evaluate modified schedule, forecast impact resulted from unexpected disruptions, and conduct various what-if analysis. Reactive and proactive scheduling algorithms have been developed in the simulation system to resolve unforeseen disruptions and increase the robustness of the solutions. Experiments on a real-world case study of a technology-intensive industrial product development program have been conducted to …