作者
Daniel K Wells, Marit M van Buuren, Kristen K Dang, Vanessa M Hubbard-Lucey, Kathleen CF Sheehan, Katie M Campbell, Andrew Lamb, Jeffrey P Ward, John Sidney, Ana B Blazquez, Andrew J Rech, Jesse M Zaretsky, Begonya Comin-Anduix, Alphonsus HC Ng, William Chour, V Yu Thomas, Hira Rizvi, Jia M Chen, Patrice Manning, Gabriela M Steiner, Xengie C Doan, Aly A Khan, Amit Lugade, Ana M Mijalkovic Lazic, Angela A Elizabeth Frentzen, Arbel D Tadmor, Ariella S Sasson, Arjun A Rao, Baikang Pei, Barbara Schrörs, Beata Berent-Maoz, Beatriz M Carreno, Bin Song, Bjoern Peters, Bo Li, Brandon W Higgs, Brian J Stevenson, Christian Iseli, Christopher A Miller, Christopher A Morehouse, Cornelis JM Melief, Cristina Puig-Saus, Daphne van Beek, David Balli, David Gfeller, David Haussler, Dirk Jäger, Eduardo Cortes, Ekaterina Esaulova, Elham Sherafat, Francisco Arcila, Gabor Bartha, Geng Liu, George Coukos, Guilhem Richard, Han Chang, Han Si, Inka Zörnig, Ioannis Xenarios, Ion Mandoiu, Irsan Kooi, James P Conway, Jan H Kessler, Jason A Greenbaum, Jason F Perera, Jason Harris, Jasreet Hundal, Jennifer M Shelton, Jianmin Wang, Jiaqian Wang, Joel Greshock, Jonathon Blake, Joseph Szustakowski, Julia Kodysh, Juliet Forman, Lei Wei, Leo J Lee, Lorenzo F Fanchi, Maarten Slagter, Maren Lang, Markus Mueller, Martin Lower, Mathias Vormehr, Maxim N Artyomov, Michael Kuziora, Michael Princiotta, Michal Bassani-Sternberg, Mignonette Macabali, Milica R Kojicic, Naibo Yang, Nevena M Ilic Raicevic, Nicolas Guex, Nicolas Robine, Niels Halama, Nikola M Skundric, Ognjen S Milicevic, Pascal Gellert, Patrick Jongeneel, Pornpimol Charoentong, Pramod K Srivastava, Prateek Tanden, Priyanka Shah, Qiang Hu, Ravi Gupta, Richard Chen, Robert Petit, Robert Ziman, Rolf Hilker, Sachet A Shukla, Sahar Al Seesi, Sean M Boyle, Si Qiu, Siranush Sarkizova, Sofie Salama, Song Liu, Song Wu, Sriram Sridhar, Steven LC Ketelaars, Suchit Jhunjhunwala, Tatiana Shcheglova, Thierry Schuepbach, Todd H Creasy, Veliborka Josipovic, Vladimir B Kovacevic, Weixuan Fu, Willem-Jan Krebber, Yi-Hsiang Hsu, Yinong Sebastian, Zeynep Kosaloglu-Yalcin, Zhiqin Huang, Taha Merghoub, Justin Guinney, Adam Kolom, Cheryl Selinsky, Antoni Ribas, Matthew D Hellmann, Nir Hacohen, Alessandro Sette, James R Heath, Nina Bhardwaj, Fred Ramsdell, Robert D Schreiber, Ton N Schumacher, Pia Kvistborg, Nadine A Defranoux
发表日期
2020/10/29
期刊
Cell
卷号
183
期号
3
页码范围
818-834. e13
出版商
Elsevier
简介
Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, there are no reference data to compare these approaches, and the parameters governing tumor epitope immunogenicity remain unclear. Here, we assembled a global consortium wherein each participant predicted immunogenic epitopes from shared tumor sequencing data. 608 epitopes were subsequently assessed for T cell binding in patient-matched samples. By integrating peptide features associated with presentation and recognition, we developed a model of tumor epitope immunogenicity that filtered out 98% of non-immunogenic peptides with a precision above 0.70. Pipelines prioritizing model features had superior performance, and pipeline alterations leveraging them improved prediction performance. These findings were …
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DK Wells, MM van Buuren, KK Dang… - Cell, 2020