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With increasing popularity of wearable and implantable technologies for medical applications, there is a growing concern on the security and data protection of the on-body Internet-ofThings (IoT) devices. As a solution, cryptographic system is often adopted to encrypt the data, and Random Number Generator (RNG) is of vital importance to such system. This paper proposes a new random number generation method for securing on-body IoT devices based on temporal signal variations of the outputs of the Inertial Measurement Units (IMU) worn by the users while walking. As most new wearable and implantable devices have built-in IMUs and walking gait signals can be extracted from these body sensors, this method can be applied and integrated into the cryptographic systems of these new devices. To generate the random numbers, this method divides IMU signals into gait cycles and generates bits by comparing …