作者
David R Williamson, Martin Albert, Diane Heels-Ansdell, Donald M Arnold, François Lauzier, Ryan Zarychanski, Mark Crowther, Theodore E Warkentin, Peter Dodek, John Cade, Olivier Lesur, Wendy Lim, Robert Fowler, Francois Lamontagne, Stephan Langevin, Andreas Freitag, John Muscedere, Jan O Friedrich, William Geerts, Lisa Burry, Jamal Alhashemi, Deborah Cook
发表日期
2013/10/1
期刊
Chest
卷号
144
期号
4
页码范围
1207-1215
出版商
Elsevier
简介
Background
Thrombocytopenia is the most common hemostatic disorder in critically ill patients. The objective of this study was to describe the incidence, risk factors, and outcomes of thrombocytopenia in patients admitted to medical-surgical ICUs.
Methods
Three thousand seven hundred forty-six patients in 67 centers were enrolled in a randomized trial in which unfractionated heparin was compared with low-molecular-weight heparin (LMWH) for thromboprophylaxis. Patients who had baseline platelet counts < 75 × 109/L or severe coagulopathy at screening were excluded. We analyzed the risk of developing mild (100-149 × 109/L), moderate (50-99 × 109/L), and severe (< 50 × 109/L) thrombocytopenia during an ICU stay. We also assessed independent and time-varying predictors of thrombocytopenia and the effect of thrombocytopenia on major bleeding, transfusions, and death.
Results
The incidences of mild …
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DR Williamson, M Albert, D Heels-Ansdell, DM Arnold… - Chest, 2013