作者
Gloria Brea-Calvo, Ángeles Rodríguez-Hernández, Daniel JM Fernández-Ayala, Plácido Navas, José A Sánchez-Alcázar
发表日期
2006/4/15
期刊
Free Radical Biology and Medicine
卷号
40
期号
8
页码范围
1293-1302
出版商
Pergamon
简介
Free radicals have been implicated in the action of many chemotherapeutic drugs. Here we tested the hypothesis that camptothecin and other chemotherapeutic drugs, such as etoposide, doxorubicin, and methotrexate, induce an increase in coenzyme Q10 levels as part of the antioxidant defense against free radical production under these anticancer treatments in cancer cell lines. Chemotherapy treatment induced both free radical production and an increase in coenzyme Q10 levels in all the cancer cell lines tested. Reduced coenzyme Q10 form levels were particularly enhanced. Coenzyme Q10-increased levels were associated with up-regulation of COQ genes expression, involved in coenzyme Q10 biosynthesis. At the translational level, COQ7 protein expression levels were also increased. Furthermore, coenzyme Q10 biosynthesis inhibition blocked camptothecin-induced coenzyme Q10 increase, and …
引用总数
学术搜索中的文章
G Brea-Calvo, Á Rodríguez-Hernández… - Free Radical Biology and Medicine, 2006