作者
Rosario Menéndez, José Miguel Sahuquillo-Arce, Soledad Reyes, Raquel Martínez, Eva Polverino, Catia Cillóniz, Juan Ginés Córdoba, Beatriz Montull, Antoni Torres
发表日期
2012/6/1
期刊
Chest
卷号
141
期号
6
页码范围
1537-1545
出版商
Elsevier
简介
Background
The inflammatory response in community-acquired pneumonia (CAP) depends on the host and on the challenge of the causal microorganism. Here, we analyze the patterns of inflammatory cytokines, procalcitonin (PCT), and C-reactive protein (CRP) in order to determine their diagnostic value.
Methods
This was a prospective study of 658 patients admitted with CAP. PCT and CRP were analyzed by immunoluminometric and immunoturbidimetric assays. Cytokines (tumor necrosis factor-α [TNF-α], IL-1β, IL-6, IL-8, and IL-10) were measured using enzyme immunoassay.
Results
The lowest medians of CRP, PCT, TNF-α, and IL-6 were found in CAP of unknown cause, and the highest were found in patients with positive blood cultures. Different cytokine profiles and biomarkers were found depending on cause: atypical bacteria (lower PCT and IL-6), viruses (lower PCT and higher IL-10), Enterobacteriaceae …
学术搜索中的文章
R Menéndez, JM Sahuquillo-Arce, S Reyes, R Martínez… - Chest, 2012