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Microarray is an efficacious tool used to detect, analyze and describe local features of the genome in the form of an image. A microarray is glass slide which consists of different nucleic acid inquest added chemically. Microarray provides enough guidance on infection pathology, progression, resistance to treatment, and response to cellular microenvironments and ultimately may lead to improved and innovative approaches for disease diagnosis. Study of microarray includes these steps: initially spot addressing followed by spot separation as background and foreground and finally intensity extraction of separated spots. In the spot separation stage, extended k-means and Fast EM methods are proposed. The proposed method is a heuristic approach where Coefficient-Variation of the input image is used as a metric to switch the image for segmentation to the appropriate existing method as well as to the …