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Networks have evolved very rapidly, which allow secret data transformation speedily through the Internet. However, the security of secret data has posed a serious threat due to openness of these networks. Thus, researchers draw their attention on cryptography field for this reason. Due to the traditional cryptographic techniques which are vulnerable to intruders nowadays. Deoxyribonucleic Acid (DNA) considered as a promising technology for cryptography field due to extraordinary data density and vast parallelism. With the help of the various DNA arithmetic and biological operations are also Blum Blum Shub (BBS) generator, a multi-level of DNA encryption algorithm is proposed here. The algorithm first uses the dynamic key generation to encrypt sensitive information as a first level; second, it uses BBS generator to generate a random DNA sequence; third, the BBS-DNA sequence spliced with a DNA Gen Bank …