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The Data Compression is a creative skill which defined scientific concepts of providing contents in a compact form. Thus, it has turned into a need in the field of communication as well as in different scientific studies. Data transmission must be sufficiently secure to be utilized in a channel medium with no misfortune; and altering of information. Encryption is the way toward scrambling an information with the goal that just the known receiver can peruse or see it. Encryption can give methods for anchoring data. Along these lines, the two strategies are the two crucial advances that required for the protected transmission of huge measure of information. In typical cases, the compacted information is encoded and transmitted. In any case, this sequential technique is time consumption and computationally cost. In the present paper, an examination on simultaneous compression and encryption technique depends on DNA …