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In this paper, a control approach for improving the overall efficiency of a wastewater treatment plant (WWTP) is presented. It consists of a cascaded control system that uses a global performance indicator as the controlled variable to drive the plant to operating conditions that satisfies trade-offs involved in the WWTP operation, improving the global performance of the plant. The selected global performance indicator is the N/E index that measures the ratio between the amount of nitrogenated compounds eliminated (kgN) and the energy (kWh) required to achieve that goal. This index links the variables of the activated sludge process with the energy consumed in the whole plant, thus the control strategy takes actions based on plantwide considerations. An external Proportional Integral (PI) controller changes the DO set point according to the N/E index and the basic dissolved oxygen (DO) control scheme in the activated sludge process follows this reference changes varying the aeration intensity. An outer loop with an event-based controller is used to compute the index values when the DO concentration is driven to excessively low limits, preventing long operation periods in this undesirable condition. Simple proportional integral controllers (PI) are used to adapt the strategy to the automation systems available in WWTPs. The implementation in the Benchmark Simulation Model 2 (BSM2) demonstrates the potential of the proposed approach. The results show the possibilities of the N/E index to be used as an indicator of global performance of WWTPs. It provides a link between water line objectives and energy consumption in the whole plant that can …