作者
Álvaro Aparisi, Carolina Iglesias-Echeverría, Cristina Ybarra-Falcón, Iván Cusácovich, Aitor Uribarri, Mario García-Gómez, Raquel Ladrón, Raúl Fuertes, Jordi Candela, Javier Tobar, Williams Hinojosa, Carlos Dueñas, Roberto González, Leonor Nogales, Dolores Calvo, Manuel Carrasco-Moraleja, J Alberto San Román, Ignacio J Amat-Santos, David Andaluz-Ojeda
发表日期
2021/8/26
期刊
Nutrition, Metabolism and Cardiovascular Diseases
卷号
31
期号
9
页码范围
2619-2627
出版商
Elsevier
简介
Background and aims
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the sole causative agent of coronavirus infectious disease-19 (COVID-19).
Methods and results
We performed a retrospective single-center study of consecutively admitted patients between March 1st and May 15th, 2020, with a definitive diagnosis of SARS-CoV-2 infection. The primary end-point was to evaluate the association of lipid markers with 30-days all-cause mortality in COVID-19.
A total of 654 patients were enrolled, with an estimated 30-day mortality of 22.8% (149 patients). Non-survivors had lower total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) levels during the entire course of the disease. Both showed a significant inverse correlation with inflammatory markers and a positive correlation with lymphocyte count. In a multivariate analysis, LDL-c ≤ 69 mg/dl (hazard ratio [HR] 1.94; 95% confidence …
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Á Aparisi, C Iglesias-Echeverría, C Ybarra-Falcón… - Nutrition, Metabolism and Cardiovascular Diseases, 2021