作者
Philip C Spinella, Marisa Tucci, Dean A Fergusson, Jacques Lacroix, Paul C Hébert, Stéphane Leteurtre, Kenneth B Schechtman, Allan Doctor, Robert A Berg, Tina Bockelmann, J Jaime Caro, Fabrizio Chiusolo, Lucy Clayton, Jill M Cholette, Gonzalo Garcia Guerra, Cassandra D Josephson, Kusum Menon, Jennifer A Muszynski, Marianne E Nellis, Amrita Sarpal, Stephanie Schafer, Marie E Steiner, Alexis F Turgeon, ABC-PICU Investigators, Canadian Critical Care Trials Group, Pediatric Acute Lung Injury and Sepsis Investigators Network
发表日期
2019/12/10
期刊
Jama
卷号
322
期号
22
页码范围
2179-2190
出版商
American Medical Association
简介
Importance
The clinical consequences of red blood cell storage age for critically ill pediatric patients have not been examined in a large, randomized clinical trial.
Objective
To determine if the transfusion of fresh red blood cells (stored ≤7 days) reduced new or progressive multiple organ dysfunction syndrome compared with the use of standard-issue red blood cells in critically ill children.
Design, Setting, and Participants
The Age of Transfused Blood in Critically-Ill Children trial was an international, multicenter, blinded, randomized clinical trial, performed between February 2014 and November 2018 in 50 tertiary care centers. Pediatric patients between the ages of 3 days and 16 years were eligible if the first red blood cell transfusion was administered within 7 days of intensive care unit admission. A total of 15 568 patients were screened, and 13 308 were excluded.
Interventions
Patients were randomized to receive …
学术搜索中的文章
PC Spinella, M Tucci, DA Fergusson, J Lacroix… - Jama, 2019