作者
Walied M Alarif, Doaa F Baamer, Mohamed A Ghandourah, Hajer S Alorfi, Najla A Alburae, Fitri Budiyanto, Ashraf B Abdel-Naim
发表日期
2023/4
期刊
Environmental Science and Pollution Research
卷号
30
期号
19
页码范围
56920-56929
出版商
Springer Berlin Heidelberg
简介
The soft-bodied corals of the genera Sarcophyton and Sinularia (Alcyoniidae) are known as a warehouse of casbane and cembranoid diterpenoids with remarkable antitumor effects. Two casbane-type diterpenoids (1, 2) along with four cembrane-type diterpenoids (3–6) were isolated from the diethyl ether soluble fraction of the organic extracts of the Red Sea soft corals Sinularia leptoclados and Sarcophyton glaucum, respectively. The antiproliferative activity of all isolated compounds (1–6) against three hepatocellular carcinoma cells, namely, Huh-7, SNU 499, and HepG2, along with the normal cells EA.hy 926, was evaluated. Sinueracabanone D (1) displayed a remarkable antiproliferative effect against the examined cancer cell lines, especially HepG2 cells with IC50 of 4.0 ± 0.37 µM. Cell cycle analysis indicated compound 1 caused the accumulation of HepG2 cells in the G2/M-phase. Further, compound 1 …
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WM Alarif, DF Baamer, MA Ghandourah, HS Alorfi… - Environmental Science and Pollution Research, 2023