作者
Mengliang Wu, Xinyuan Zhang, Senuri Karunaratne, Ji-hyun Lee, Edwin R Lampugnani, Kevin J Selva, Amy W Chung, Scott N Mueller, Holly R Chinnery, Laura E Downie
发表日期
2024/5/3
期刊
Ophthalmology
出版商
Elsevier
简介
Purpose
While the external environment has been shown to shape the systemic human immune landscape, defining the in vivo immune status of peripheral tissues has remained a technical challenge. We recently developed functional in vivo confocal microscopy (Fun-IVCM) for dynamic, longitudinal imaging of corneal immune cells in living humans. This study investigated the effect of seasonal-driven environmental factors on the density, morphology and dynamic behavior of human corneal immune cell subsets.
Design
Longitudinal, observational clinical study.
Participants
Sixteen healthy participants (18-40 years) attended two visits in distinct seasons in Melbourne, Australia (Visit 1: Spring/Summer: November-December 2021; Visit 2: Autumn/Winter: April-June 2022).
Methods
Environmental data were collected over each period. Participants underwent ocular surface examinations and corneal Fun-IVCM …
学术搜索中的文章
M Wu, X Zhang, S Karunaratne, J Lee, ER Lampugnani… - Ophthalmology, 2024