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Supplier selection for strategic items requires a comprehensive framework dealing with qualitative and quantitative aspects of a company’s competitive priorities and supply risk, decision scope, and uncertainty. In order to address these aspects, this study aims to tackle supplier selection for strategic items with a multi-sourcing, taking into account multi-criteria, incorporating uncertainty of decision-makers judgment and supplier–buyer parameters, and integrating with inventory management which the past studies have not addressed well. We develop a novel two-phase solution approach based on integrated multi-criteria decision-making (MCDM) and multi-objective simulation-optimization (S-O). First, MCDM methods, including fuzzy AHP and interval TOPSIS, are applied to calculate suppliers’ scores, incorporating uncertain decision makers’ judgment. S-O then combines the (quantitative) cost-related criteria and …