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As the cost of human full genome sequencing continues to fall, we will soon witness a prodigious amount of human genomic data in the public cloud. To protect the confidentiality of the genetic information of individuals, the data has to be encrypted at rest. On the other hand, encryption severely hinders the use of this valuable information, such as Genome-wide Range Query (GRQ), in medical/genomic research. While the problem of secure range query on outsourced encrypted data has been extensively studied, the current schemes are far from practical deployment in terms of efficiency and scalability due to the data volume in human genome sequencing. In this paper, we investigate the problem of secure GRQ over human raw aligned genomic data in a third-party outsourcing model. Our solution contains a novel secure range query scheme based on multi-keyword symmetric searchable encryption (MSSE). The …