作者
Aaron Reuben, Karen Sugden, Louise Arseneault, David L Corcoran, Andrea Danese, Helen L Fisher, Terrie E Moffitt, Joanne B Newbury, Candice Odgers, Joey Prinz, Line JH Rasmussen, Ben Williams, Jonathan Mill, Avshalom Caspi
发表日期
2020/6/1
期刊
JAMA Network Open
卷号
3
期号
6
页码范围
e206095-e206095
出版商
American Medical Association
简介
Importance
DNA methylation has been proposed as an epigenetic mechanism by which the childhood neighborhood environment may have implications for the genome that compromise adult health.
Objective
To ascertain whether childhood neighborhood socioeconomic disadvantage is associated with differences in DNA methylation by age 18 years.
Design, Setting, and Participants
This longitudinal cohort study analyzed data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative birth cohort of children born between 1994 and 1995 in England and Wales and followed up from age 5 to 18 years. Data analysis was performed from March 15, 2019, to June 30, 2019.
Exposures
High-resolution neighborhood data (indexing deprivation, dilapidation, disconnection, and dangerousness) collected across childhood.
Main Outcomes and Measures
DNA methylation in whole blood was …
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A Reuben, K Sugden, L Arseneault, DL Corcoran… - JAMA Network Open, 2020