作者
Andrew M Novick, Leah C Miiller, Gina L Forster, Michael J Watt
发表日期
2013/12
期刊
Behavioral and Brain Functions
卷号
9
页码范围
1-11
出版商
BioMed Central
简介
Background
Adolescent social stress is associated with increased incidence of mental illnesses in adulthood that are characterized by deficits in cognitive focus and flexibility. Such enhanced vulnerability may be due to psychosocial stress-induced disruption of the developing mesocortical dopamine system, which plays a fundamental role in facilitating complex cognitive processes such as spatial working memory. Adolescent rats exposed to repeated social defeat as a model of social stress develop dopaminergic hypofunction in the medial prefrontal cortex as adults. To evaluate a direct link between adolescent social stress and later deficits in cognitive function, the present study tested the effects of adolescent social defeat on two separate tests of spatial working memory performance.
Methods
Adult rats exposed to adolescent social defeat and their …
学术搜索中的文章
AM Novick, LC Miiller, GL Forster, MJ Watt - Behavioral and Brain Functions, 2013