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Soft tissue sarcomas (STSs) are a relatively rare group of heterogeneous tumors derived from mesenchymal tissue elements. An STS can occur at any age, accounting for less than 1% of all adult solid tumors and about 7% of pediatric malignancies. As a result, STSs are the cause of 2% of all cancer-related deaths. 1, 2 Typically, the clinical manifestation of an STS is of a heterogeneous soft tissue mass that grows over time. Symptoms usually develop due to the mass effect on nerves, vessels, and other adjacent structures. The anatomic locations at which STSs of musculoskeletal origin most often occur are the extremities (70%), followed by the thoracic wall. 3 Within these locations, the muscular compartments are the most common spaces. Distinguishing between the more than 50 discrete histologic subtypes of STSs is possible through tissue biopsy. In adults, the most common histologic subtypes are liposarcoma …