作者
Alis Yovana Pataquiva Mateus, Cristina C Barrias, Cristina Ribeiro, Maria P Ferraz, Fernando J Monteiro
发表日期
2008/8
期刊
Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials
卷号
86
期号
2
页码范围
483-493
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
This study concerns the preparation, physical, and in vitro characterization of two different types of hydroxyapatite (HA) microspheres, which are intended to be used as drug‐delivery systems and bone‐regeneration matrices. Hydroxyapatite nanoparticles (HA‐1 and HA‐2) were prepared using the chemical precipitation synthesis with H3PO4, Ca(OH)2, and a surfactant, SDS (sodium dodecyl sulfate), as starting reagents. The HA powders were dispersed in a sodium alginate solution, and spherical particles were obtained by droplet extrusion coupled with ionotropic gelation in the presence of Ca2+. These were subsequently sintered to produce HA‐1 and HA‐2 microspheres with a uniform size and interconnected microporosity. Both powders and microspheres were characterized using FTIR and X‐ray diffraction. Moreover, SEM and mercury intrusion porosimetry were used to analyze the microspheres, and TEM …
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AYP Mateus, CC Barrias, C Ribeiro, MP Ferraz… - Journal of Biomedical Materials Research Part A: An …, 2008