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This study concerns the preparation, physical, and in vitro characterization of two different types of hydroxyapatite (HA) microspheres, which are intended to be used as drug‐delivery systems and bone‐regeneration matrices. Hydroxyapatite nanoparticles (HA‐1 and HA‐2) were prepared using the chemical precipitation synthesis with H₃PO₄, Ca(OH)₂, and a surfactant, SDS (sodium dodecyl sulfate), as starting reagents. The HA powders were dispersed in a sodium alginate solution, and spherical particles were obtained by droplet extrusion coupled with ionotropic gelation in the presence of Ca²⁺. These were subsequently sintered to produce HA‐1 and HA‐2 microspheres with a uniform size and interconnected microporosity. Both powders and microspheres were characterized using FTIR and X‐ray diffraction. Moreover, SEM and mercury intrusion porosimetry were used to analyze the microspheres, and TEM …