作者
Eric C Porges, Adam J Woods, Richard AE Edden, Nicolaas AJ Puts, Ashley D Harris, Huaihou Chen, Amanda M Garcia, Talia R Seider, Damon G Lamb, John B Williamson, Ronald A Cohen
发表日期
2017/1/1
期刊
Biological psychiatry: cognitive neuroscience and neuroimaging
卷号
2
期号
1
页码范围
38-44
出版商
Elsevier
简介
Background
Gamma-aminobutyric acid (GABA), the brain’s principal inhibitory neurotransmitter, has been associated with perceptual and attentional functioning. Recent application of magnetic resonance spectroscopy (MRS) provides in vivo evidence for decreasing GABA concentrations during adulthood. It is unclear, however, how age-related decrements in cerebral GABA concentrations contribute to cognitive decline, or whether previously reported declines in cerebral GABA concentrations persist during healthy aging. We hypothesized that participants with higher GABA concentrations in the frontal cortex would exhibit superior cognitive function and that previously reported age-related decreases in cortical GABA concentrations continue into old age.
Methods
We measured GABA concentrations in frontal and posterior midline cerebral regions using a Mescher-Garwood point-resolved spectroscopy (MEGA …
学术搜索中的文章
EC Porges, AJ Woods, RAE Edden, NAJ Puts… - Biological psychiatry: cognitive neuroscience and …, 2017