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We demonstrate that certain combinations of non-rotationally symmetric aberrations (coma and astigmatism) can improve retinal image quality over the condition with the same amount of astigmatism alone. Simulations of the retinal image quality in terms of Strehl Ratio, and measurements of Visual Acuity under controlled aberrations with adaptive optics were performed, varying defocus, astigmatism and coma. Astigmatism ranged between 0 and 1.5D. Defocus ranged typically between −1 and 1D. The amount of coma producing best retinal image quality (for a given relative angle between astigmatism and coma) was computed and the amount was found to be different from zero in all cases (except for 0D of astigmatism). For example, for a 6mm pupil, in the presence of 0.5D of astigmatism, a value of coma of 0.23μm produced (for best focus) a peak improvement in Strehl Ratio by a factor of 1.7, over having 0.5D of …