作者
Shu-Fen Liao, Chun-Yun Su, Mei-Hsin Su, Cheng-Yun Chen, Chia-Yen Chen, Yen-Feng Lin, Yi-Jiun Pan, Po-Chang Hsiao, Pei-Chun Chen, Yen-Tsung Huang, Chi-Shin Wu, Shi-Heng Wang
发表日期
2023/1/1
期刊
Journal of Affective Disorders
卷号
320
页码范围
397-403
出版商
Elsevier
简介
Background
The comorbidity of obesity and major depressive disorder (MDD) may be attributable to a bidirectional relationship and shared genetic influence. We aimed to examine the polygenic associations between obesity and MDD and to characterize their corresponding impacts on the obesity mechanism.
Methods
Genome-wide genotyping was available in 106,604 unrelated individuals from Taiwan Biobank. Polygenic risk score (PRS) for body mass index (BMI) and MDD was derived to evaluate their effects on obesity-related traits. Stratified analyses were performed for the modified effect of depression on the polygenic associations.
Results
The MDD PRS was positively associated with waistline (beta in per SD increase in PRS = 0.12), hipline (beta = 0.08), waist-hip ratio (WHR) (beta = 0.05), body fat rate (beta = 0.08), BMI (beta = 0.05), overweight (OR = 1.02 for BMI ≥ 25), and obesity (OR = 1.05 for BMI ≥ 30 …
学术搜索中的文章
SF Liao, CY Su, MH Su, CY Chen, CY Chen, YF Lin… - Journal of Affective Disorders, 2023