作者
Yuan Li, Fan Yang, Manqi Gao, Rui Gong, Mengyu Jin, Tianyi Liu, YI Sun, Yutuo Fu, Qi Huang, Wenwen Zhang, Shenzhen Liu, Meixi Yu, Gege Yan, Chao Feng, Mingyu He, Lai Zhang, Fengzhi Ding, Wenya Ma, Zhenggang Bi, Chaoqian Xu, Ye Yuan, Benzhi Cai, Lei Yang
发表日期
2019/9/6
期刊
Molecular Therapy-Nucleic Acids
卷号
17
页码范围
590-600
出版商
Elsevier
简介
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell differentiation program is crucial to the bone microenvironment and bone development. MicroRNAs (miRNAs) have played a critical role in regulating the differentiation of BMSCs into particular lineage. However, the role of miR-149-3p in the adipogenic and osteogenic differentiation of BMSCs has not been extensively discovered. In this study, we aimed to detect the expression levels of miR-149-3p during the differentiation of BMSCs and investigate whether miR-149-3p participated in the lineage choice of BMSCs or not. Compared with mimic-negative control (NC), miR-149-3p mimic decreased the adipogenic differentiation potential of BMSCs and increased the osteogenic differentiation potential. Further analysis revealed that …
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Y Li, F Yang, M Gao, R Gong, M Jin, T Liu, YI Sun, Y Fu… - Molecular Therapy-Nucleic Acids, 2019