作者
Christopher D Buckley, Darrell Pilling, Janet M Lord, Arne N Akbar, Dagmar Scheel-Toellner, Mike Salmon
发表日期
2001/4/1
来源
Trends in immunology
卷号
22
期号
4
页码范围
199-204
出版商
Elsevier
简介
Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.
引用总数
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CD Buckley, D Pilling, JM Lord, AN Akbar… - Trends in immunology, 2001