作者
SK Butcher, Hemalata Chahal, L Nayak, Alan Sinclair, NV Henriquez, Elizabeth Sapey, D O'mahony, JM Lord
发表日期
2001/12
期刊
Journal of leukocyte biology
卷号
70
期号
6
页码范围
881-886
出版商
Oxford University Press
简介
Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23–35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was slightly increased in neutrophils from elderly donors, and serum from the elderly was able to opsonize E. coli efficiently. In contrast, phagocytic index was significantly lower in neutrophils from the elderly, compared with young donors (P<0.005). CD11a and CD11b expression was not affected by age, but CD16 was significantly reduced in neutrophils from elderly donors (P<0.0001). CD16 expression and phagocytic index were measured in the same neutrophils using FITC-labeled E. coli, PE-conjugated anti-CD16 antibody, and CD16 expression correlated with phagocytic index (r=0.83;P<0 …
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SK Butcher, H Chahal, L Nayak, A Sinclair… - Journal of leukocyte biology, 2001